RESUMO
Cytogenetic and mitotic disorders were studied in 151 patients with acute non-lymphoblastic leukemia. A significant rise in the incidence of clonal disorders with predominant affection of chromosomes 5 and 7, and an increase in the percentage of cases with the presence of pathologic mitoses in hemopoietic cells have been recorded in patients who, due to their occupation, have been exposed to potentially mutagenic chemical substances.
Assuntos
Poluentes Ocupacionais do Ar/efeitos adversos , Indústria Química , Aberrações Cromossômicas/genética , Cromossomos Humanos Par 5/efeitos dos fármacos , Cromossomos Humanos Par 7/efeitos dos fármacos , Leucemia Mieloide Aguda/genética , Mitose/efeitos dos fármacos , Doenças Profissionais/genética , Humanos , Leucemia Mieloide Aguda/induzido quimicamente , Doenças Profissionais/induzido quimicamente , U.R.S.S.RESUMO
Certain occupational groups demonstrate some deviations in the peripheral blood parameters which can be regarded as a multi-component hematological trait for selection of the group to be placed under observation.
Assuntos
Condução de Veículo , Biomarcadores Tumorais/sangue , Indústria Química , Leucocitose/sangue , Leucopenia/sangue , Doenças Profissionais/sangue , Feminino , República da Geórgia , Humanos , Leucemia Mieloide Aguda/sangue , Leucemia Mieloide Aguda/etiologia , Contagem de Leucócitos , Leucocitose/classificação , Leucopenia/classificação , Masculino , Doenças Profissionais/etiologia , Pré-Leucemia/sangue , Pré-Leucemia/etiologia , Fatores de RiscoRESUMO
The analysis of the epidemiological data has evidenced that there exist common factors of the development of varying types of depressions and dysplasias of hemopoiesis and acute non-lymphoblastic leukemias, and has shown the possibility of distinguishing common risk groups in respect to these diseases.
